To understand insulin resistance, it helps to understand a little about how insulin works and its role in the body. Insulin is an essential hormone created in the pancreas, which is involved in the metabolism of sugars in the body. Without it, we can not turn the food we eat into usable energy.
When we eat something, a lot of digested food is converted into glucose, the main energy source of the body. The pancreas then responds to blood sugar levels by secreting insulin in increasing the flow of blood. Most cells in your body contain insulin receptors that help insulin bind to the cell. Once insulin binds to the cell, activate other receptor sites, allowing glucose to enter the cell and provide energy for life.
The 
Since 2007 in Germany is going a combined therapy of the drug pioglitazone with insulin. First interim analysis was recently published. These indicate that the combination in the future is both effective and safe.
