Diabetes Treatment Weblog

Posts Tagged ‘insulin’

A new vaccine to protect children with low glucose tolerance before an impending type 1 diabetes. Whether this is really possible, is now finally prove, inter alia, a study of the Technical University of Munich.

A type-1 diabetes develops when the immune system attacks a bad reaction in one’s own pancreas and destroys the insulin-producing cells. Due to an inflammatory reaction, which takes different lengths, the pancreas can no longer fulfill their function and diabetes becomes apparent. The onset of diabetes may last, depending on the injury, so that even ill babies or adults only. How it but at the slip of the immune system, so the exact cause of diabetes, occurs remains unclear.

Vaccination against type 1 diabetes?
If several relatives of a child have type 1 diabetes are affected, the genetic risk for the child greatly increases also suffer from diabetes too. Now by contrast, could potentially help the early administration of small doses of insulin as a kind of vaccination. Unlike type-1-Diabektikern with overt diabetes, the insulin for at-risk children do not serve to lower their blood sugar. It affects the immune system and prevent the fatal bad reaction to the pancreas in the long run. Two studies will now investigate in Austria, Italy, Britain, Canada, the USA and in Germany, how much insulin is suitable for the prevention and how it needs to be taken. The hormone could for example be administered in very small doses by mouth or as a nasal spray. When taken orally, insulin has no blood glucose-lowering effect, because it is ineffective by the stomach acid. With the hormone only children should be treated, although they are burdened with a high hereditary risk of diabetes, but still show no symptoms of the disease.

Who can participate in the prevention trial?
In Germany, experimental subjects aged 18 months to 7 years to be searched, where a family history is given with diabetes. Notes for a high risk of disease include pre-existing diabetes type 1 disease among siblings or their own parents. Before study participation, the individual risk of diabetes of the participating child is determined. The examinations and treatments during the studies are free of charge to participating families. The study is supported by the German Federal Ministry for Education and Research and the American Foundation for Diabetes Study. The study is called “pre-point” and is conducted in Germany by Professor Ezio Bonifacio at the TU Munich. For the 18-month study will be looking for a total of 40 children.

All over the world celebrated World Diabetes Day, a date important to make people aware about this disease. Organized jointly by the International Diabetes Federation (IDF, for its acronym in English) and the World Health Organization (WHO), this celebration took place on Saturday 14 November.

The World Diabetes Day is an important vehicle for all countries to ensure that people know the true magnitude of the problem of diabetes, a disease that currently affects approximately 220 million people, according to official figures published on the site WHO web.

How could it be otherwise, the secretary general of the United Nations, Ban Ki-moon issued a message in the context of World Diabetes Day, which was published in full in the official website of the international organization.

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Diabetes is a disease that may have people of all ages (currently affects almost 220 million human beings in the world, said months ago this health blog). Then there will be a newspaper article about what there is to know about diabetes.

Diabetes is defined as a metabolic disorder that involves having blood glucose (sugar) levels above the levels set. Is taken as normal blood levels between 70 and 100 mg / dl fasting. When levels exceed these values, in chronic form begins with lesions in organs like the heart, eyes, kidneys, nerves, feet and blood vessels.

Importantly, there are different types of diabetes: Type 1 diabetes is characterized by the absence of synthesis of insulin in type 2 diabetes which has its origin in the body’s inability to effectively use the insulin (the most common and can be prevented) and the so-called “gestational diabetes” which was first discovered during the stage of pregnancy.

In another vein, it is necessary to add that there are certain factors that are associated with diabetes, obesity, stress, poor diet, family history and / or hypertension.

People with diabetes may reduce these risk factors and live a normal life. For this, you must acquire some patterns of behavior such as physical exercise, a controlled medication, a balanced diet as well as having a regular medical checks.

Explains research materials for the realization of this note, which was compiled by the website Cardiosalud.org, patients with this disease can achieve a good quality of life depending on the habits they acquire.

It is important to add that this disease affects about 220 million people, according to official figures published on the website of the World Health Organization (WHO) on the occasion of World Diabetes Day, which were published months ago in this blog.

Alice Posada has marked in her memory December 26, 2006, the day they discovered that her daughter Emily had diabetes type I, a metabolic disease that requires daily insulin injections.

Her daughter, then 18-months old, was rushed and spent several days in the hospital tested until doctors were able to determine the dose of insulin needed to balance your blood sugar level. “I do not understand anything, it was blank,” said Alice to voanoticias.com, who until now had no close relative with Type I diabetes

Hospital Alice and her husband came up with an idea of how the metabolism of Emilia, what dose of insulin would need daily, what kind of diet should continue and at what times I had to eat. In practice, this meant a total rethinking of their lives. Alice had to leave her job of 10 years as a clerk in a blood bank to provide care for her daughter. And over the years, she and her family learned to overcome their fears and prepare for future obstacles.

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Are diagnosed each year in Spain, 1,100 new cases of diabetes in children and much of it is detected late. Thus, 45% of children between 5 and 10 years who are diagnosed with diabetes also show state of ketoacidosis, a serious complication that is due to a very marked lack of insulin.

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Temporary resistance to insulin during pregnancy. The so-called gestational diabetes occurring during pregnancy at a rate of 1% to 14% of patients, and almost always debut between 24 and 28 weeks of pregnancy.

Sometimes it may persist after birth and is associated with increased maternal disorders (hypertension or high blood pressure, vaginal infections and urinary tract, premature delivery and caesarean) and serious harm to the baby (macrosomia fetal death, ie overgrowth of the product because it is exposed to more glucose than usual this is because it stimulates your pancreas secretes insulin abundance increases their development, which can lead to injury at the time of passing through the birth canal .)

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Since 2007 in Germany is going a combined therapy of the drug pioglitazone with insulin. First interim analysis was recently published. These indicate that the combination in the future is both effective and safe.

The type 2 diabetes
Type-2 diabetes have a resistance of body cells to the biological effects of insulin. Once this so-called insulin resistance is too strong, does the injected insulin in a diabetes therapy is not effective enough. Be increased in these cases, the insulin sensitivity by insulin sensitizers. These sensitizers are firstly used for type-2 diabetes with marked insulin resistance, ie, in patients in whom insulin alone is insufficient. On the other hand in diabetic patients who are not the standard combination of insulin and metformin because of contraindications or intolerance can take.

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In Germany, a type-2 diabetes is often treated with tablets. These are relatively easy to handle and do not require intensive training as they are common for insulin users. Nevertheless, type-2 diabetes have a relatively high risk for atherosclerosis and heart disease. A new study has dealt with the question of which treatment option for type 2 diabetes cheap.

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Type 2 diabetes and other common illnesses are seen in a new light after researchers a genome map that shows which genes are found turned on or off to create ‘too. “Researchers from Barcelona and the University of North Carolina, whose realization in the pancreatic islet cells cells.Since The pancreas produces insulin, the understanding of the genes behind the organ is important to stabilize blood sugar levels.

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It is a disorder in the metabolism of carbohydrates, fats and proteins caused by a deficiency of insulin, which can be absolute or relative. For its part, insulin is a hormone produced by the beta cells of pancreas to control blood sugar (blood glucose levels).
Insulin deficiency causes impairment in the ability of tissues to utilize nutrients, resulting in increased blood glucose (hyperglycaemia).

Normally, when glucose exceeds 110 mg / dl is secreted insulin and low blood sugar to normal (80-110 mg / dl). When the blood sugar falls below 60 mg / dl, normal production slows insulin, which limits the use of glucose by the tissues and allows increased blood glucose to normal.

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